Botswana is considered one of the safest countries in Africa to travel in. Tourism is welcomed and valued by the locals in general, as it brings opportunities and income. There is no reason for you to feel unsafe anywhere in Botswana, as there have been very few reported incidents of petty theft or other opportunistic crimes.
It’s always a good idea for you to know where your valuable items are stored while traveling and not to neglect common sense when safeguarding your possessions. The most likely place an incident would occur would be near a town and not in the national parks, so the areas to remain vigilant would be at petrol stations or parking lots where opportunists might linger.