There are no mandatory vaccinations required for entering Botswana. Still, it’s essential to consider the surrounding countries that might require vaccinations if travelers will be crossing borders during their stay, e.g. Victoria Falls holiday.
Zambia requires vaccination against Yellow Fever. Regarding hepatitis and tetanus, vaccinations aren’t needed, but travelers are encouraged to consult their doctors for advice in these areas.
The same applies to malaria prophylaxis. It’s not essential, but it’s advised that visitors get an opinion from their doctors. It’s suggested that travelers spending time in high-risk areas (towns and areas with a high human density) consult their doctors for a prescription of Coartem to treat malaria.